Abstract: Clinical Evaluation of Neoadjuvant Chemotherapy in Patients with Breast CancerYunwei HAN, ShaoyanWEN,Wei LIU, XinWANGCorrespondence to: XinWANG, E-mail: xinwangse@126.comThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, ChinaAbstract Neoadjuvant chemotherapy for breast cancer (BC) has been used as an initial treatment for patients with locally ad-vanced BC before surgical resection. The use of this therapy has now been extended to patients with operable BC in an attempt todown-stage the tumors in order to successfully perform breast-conserving surgery. Traditional methods and image evaluation for predict-ing the effect of neoadjuvant chemotherapy have failed to provide accurate and reliable data. Therefore, a method of examination thatcan correctly assess the tumor changes after chemotherapy is urgently needed in clinical practice. Recently, light scattering laminagra-phy, new biological markers and analysis of cancer genomes have been introduced to clinical practice, achieving promising preliminaryoutcomes. In this article, the clinical assessment of neoadjuvant chemotherapy for BC was reviewed.Keywords Breast cancer; Neoadjuvant chemotherapy; Imaging